Approximately in 1533, he settled in Agen, where he became friends with Jules Cesar Scaliger, a famous scientist of that time.
Little is known about Notre Dame's first wife. Presumably, in 1534, he offered his hand and heart to a certain Henriette d'Encausse, who agreed to accept everything, and bore him two children: a boy and a girl.
However, family happiness did not last long. Trouble comes to their house. Wife and children die. Presumably, due to some kind of epidemic, in 1537 (39?) Year.
In 1538, also, for an unknown reason, friendship with Scaliger breaks off, and Notre Dame leaves Agen. It's time for his travels. There are traces of its presence in Italy, Germany, and, of course, in different parts of France. In 1544, he practiced medicine in Marseilles, in 1546 – in Aix-en-Provence, where he was probably granted a lifetime pension for his contribution to the fight against the plague for a reason.
November 11, 1547 he marries a second time. His chosen one is Anna Ponsard Gemellier, a widow from Salon-de-Provence, where they settle. Subsequently, they have six children: three boys and three girls: Madeleine ( 1551 г.b.), Cesar ( 1553 г.b.), Charles ( 1556 г.b.), Andre ( 1557 г.b.), Anna ( 1559 г.b.) and Diana ( 1561 г.R.).
Of all the children, fame will subsequently come to the eldest of the sons – Cesar. In addition to becoming a biographer of his father, a poet, a historian (he will write "History of Provence"), an artist, he is marked by his father in the "Prophecies".
Probably, his first book, and unpublished, Notredam wrote in 1541 (perhaps a little later), during his wanderings in Europe. It is called, for short, " ORVS APOLLO ", or "Interpretation of the hieroglyphs of Horapollo". It came down to us in the form of a manuscript, consisting of 86 sheets, and containing the embryo of the Author's cipher, about which a little later. Here I will only say that in this work the new surname of the Author appears for the first time – NOSTRADAMVS .
In 1548, he traveled around Italy, and in 1549, his first printed Almanac, a collection of astrological forecasts for the next year, was published. He, subsequently, will be published annually, until the death of the writer.
From that moment on, Nostradamus (now so) becomes famous. Then, almost in the same year, two of his works were published: “A Treatise on the Preparation of Masks and Jams” ( 1555 г.) and the first part of the main book of his life – “ LES PROPHETIES ".