German biologists have experimentally proved that transport RNA molecules could become the main element in the evolution of early life forms. Under certain conditions, they are able to assemble into functional units that reproduce genetic information exponentially.
The transfer of genetic information is carried out sequentially: first from DNA to RNA (this process is called transcription), and then protein synthesis (translation) is realized on the RNA matrix. In an operation known as replication, proteins duplicate genetic information encoded in DNA molecules and stored in the cell nucleus, distribute it equally between two daughter cells during division, and the process repeats.
The paradox of the central dogma of molecular biology is that already at the first stage, complex protein compounds – enzymes act as transcription catalysts: in a certain section, the DNA double helix is unwound under the action of enzymes, and one of the chains becomes a matrix for building the so-called matrix, or informational RNA (mRNA), which then participates in translation.
That is, at the molecular level, the age—old question arises about the origin of life – what was primary – an egg or a chicken: proteins are necessary for the transmission of genetic information, but their synthesis itself depends on transcription.
Biologists from the Ludwig and Maximilian University of Munich have experimentally proved for the first time that small changes in transport RNA (tRNA) molecules allow them to assemble themselves into a functional unit that can reproduce information.
Thus, according to scientists, transport RNA acting as an intermediary between mRNA and proteins could be a key element in the evolution of early life forms: tRNA molecules could autonomously interact with each other to form a kind of replication module capable of exponentially replicating information.
"Our studies of early forms of molecular replication and our discovery of the link between replication and translation bring us closer to reconstructing the origin of life," one of the authors of the study, Dieter Braun, is quoted in a university press release.
In order for such a system to work, a non-equilibrium environment is needed to launch the corresponding physical and chemical processes, scientists believe. Therefore, all their experiments involved a repeating sequence of temperature fluctuations.
